Methyl iodide → Methyl 4-(acetylamino)-3-nitrobenzoate

HRID 2400187

反応式

HRID 2400187 の反応式
[C:1]([NH:4][C:5]1[C:13]([N+:14]([O-:16])=[O:15])=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][C:6]=1O)(=[O:3])[CH3:2].[CH:18](N(C(C)C)CC)(C)C.CI>CN(C=O)C>[C:1]([NH:4][C:5]1[CH:6]=[CH:7][C:8]([C:9]([O:11][CH3:18])=[O:10])=[CH:12][C:13]=1[N+:14]([O-:16])=[O:15])(=[O:3])[CH3:2]

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 81531DiisopropylethylamineHCID 33646654-(Acetylamino)-3-hydroxy-5-nitrobenzoic acid

生成物 1

HCID 236856Methyl 4-(acetylamino)-3-nitrobenzoate収率 94.3%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Compound 107 (1.50 g, 6.69 mmol) was dissolved in DMF (25 mL), and diisopropylethylamine (16.0, 92.7 mmol) and MeI (2.3 mL, 39 mmol) were added. The solid which formed was filtered and the filtrate was concentrated to dryness on a rotary evaporator to provide 15 (1.50 g, 94.3%) as a yellow solid: mp 123°-124° C. (ethanol). The literature (Appleton et al., 1970) reports mp 127° C.

後処理

  1. customThe solid which formed
  2. filtrationwas filtered
  3. concentrationthe filtrate was concentrated to dryness on a rotary evaporator

出典と根拠

ORDレコード
ord-0e3cef2f91ae468d9e3d532552d23f8b
出典データセット
uspto-grants-1995_09
特許番号
US05453533

関連ノート

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