2,2-Dimethyl-1,3-dioxane-4,6-dione → 6-(Trifluoromethoxy)-2-oxo-2H-chromene-3-carboxylic acid

HRID 240034

反応式

HRID 240034 の反応式
[F:1][C:2]([F:14])([F:13])[O:3][C:4]1[CH:11]=[C:8]([CH:9]=O)[C:7]([OH:12])=[CH:6][CH:5]=1.CC1(C)O[C:21](=[O:22])[CH2:20][C:18](=[O:19])[O:17]1>O>[F:1][C:2]([F:14])([F:13])[O:3][C:4]1[CH:11]=[C:8]2[C:7](=[CH:6][CH:5]=1)[O:12][C:21](=[O:22])[C:20]([C:18]([OH:19])=[O:17])=[CH:9]2

参加物

4

反応物 2

HCID 162492,2-Dimethyl-1,3-dioxane-4,6-dioneHCID 12680582-Hydroxy-5-(trifluoromethoxy)benzaldehyde

生成物 1

HCID 100618686-(Trifluoromethoxy)-2-oxo-2H-chromene-3-carboxylic acid収率 50%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
75 °C

実験手順

5-trifluoromethoxy-salicylaldehyde (286.0 mg, 1.39 mmol) and Meldrum's acid (200 mg, 1.39 mmol) were combined in H2O (2 mL). The solution was stirred at 75° C. for 2 h. After cooling to room temperature, the precipitate was filtered and dried at suction to give 189.1 mg of 6-trifluoromethoxy-3-carboxy-coumarin in a 50% yield.

後処理

  1. temperatureAfter cooling to room temperature
  2. filtrationthe precipitate was filtered
  3. customdried at suction

出典と根拠

ORDレコード
ord-75c7661c2c424a7abc926de33611af6d
出典データセット
uspto-grants-2014_02
特許番号
US08642788B2

関連ノート

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