5-Nitro-2-pyrrolidin-1-ylmethylbenzoxazole → 2-[(Pyrrolidin-1-yl)methyl]-1,3-benzoxazol-5-amine

HRID 2400363ノート

反応式

HRID 2400363 の反応式
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[O:11][C:10]([CH2:12][N:13]3[CH2:17][CH2:16][CH2:15][CH2:14]3)=[N:9][C:8]=2[CH:18]=1)([O-])=O>[Pd].CCOC(C)=O.CO>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]2[O:11][C:10]([CH2:12][N:13]3[CH2:14][CH2:15][CH2:16][CH2:17]3)=[N:9][C:8]=2[CH:18]=1

参加物

4

反応物 1

HCID 597669925-Nitro-2-pyrrolidin-1-ylmethylbenzoxazole

生成物 1

HCID 597669972-[(Pyrrolidin-1-yl)methyl]-1,3-benzoxazol-5-amine収率 100%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 21584119Ethylacetate methanol溶媒

実験手順

To a solution of 5-nitro-2-[(pyrrolidin-1-yl)methyl]benzoxazole (300 mg, 1.21 mmol) in a mixed solvent of EtOAc-MeOH (1:1, 70 mL) was added 10% Pd—C (40 mg), the flask was purged with argon, then the argon was replaced with H2, the reaction mixture was stirred under H2 atmosphere for 30 min. After filtration through Celite, washed with ethyl acetate. The solvents were evaporated to provide 263 mg (100%) of 5-amino-2-[(pyrrolidin-1-yl)methyl]benzoxazole as a yellow solid.

後処理

  1. customthe flask was purged with argon
  2. filtrationAfter filtration through Celite
  3. washwashed with ethyl acetate
  4. customThe solvents were evaporated

出典と根拠

ORDレコード
ord-0520fc1cf16541708cae4208b71cde02
出典データセット
uspto-grants-2014_08
特許番号
US08796259B2

反応ノート

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