Trifluoroacetic acid → N-[2-[[[[(1R,2S,5R)-7-Oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]oct-2-yl]carbonyl]amino]oxy]ethyl]sulfamide
反応式
C(OC(=O)[NH:7][S:8](=[O:31])(=[O:30])[NH:9][CH2:10][CH2:11][O:12][NH:13][C:14]([C@@H:16]1[CH2:22][CH2:21][C@@H:20]2[CH2:23][N:17]1[C:18](=[O:29])[N:19]2[O:24][S:25]([OH:28])(=[O:27])=[O:26])=[O:15])(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[O:29]=[C:18]1[N:17]2[CH2:23][C@@H:20]([CH2:21][CH2:22][C@H:16]2[C:14]([NH:13][O:12][CH2:11][CH2:10][NH:9][S:8](=[O:30])(=[O:31])[NH2:7])=[O:15])[N:19]1[O:24][S:25]([OH:28])(=[O:26])=[O:27]参加物
4
反応条件
- 温度
- 0 °C
実験手順
To a mixture of tert-butyl({2-[({[(2S,5R)-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]oct-2-yl]carbonyl}amino)oxy]ethyl}sulfamoyl)carbamate 81 (0.20 g, 0.40 mmol) in DCM (5.0 mL) was added trifluoroacetic acid (1.0 mL) at 0° C. The mixture was stirred at 0° C. for 0.5 h and at room temperature for 2 h, concentrated and washed with ether. The white solid was collected by centrifugation. The crude product was purified by preparative HPLC to provide