HCID 86693977、化合物 → (2S,5R)-6-hydroxy-N-[(1-methyl-1H-imidazol-5-yl)methoxy]-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide

HRID 2400659ノート

反応式

HRID 2400659 の反応式
C([O:8][N:9]1[C:15](=[O:16])[N:14]2[CH2:17][C@H:10]1[CH2:11][CH2:12][C@H:13]2[C:18]([NH:20][O:21][CH2:22][C:23]1[N:27]([CH3:28])[CH:26]=[N:25][CH:24]=1)=[O:19])C1C=CC=CC=1>CO.[Pd]>[OH:8][N:9]1[C:15](=[O:16])[N:14]2[CH2:17][C@H:10]1[CH2:11][CH2:12][C@H:13]2[C:18]([NH:20][O:21][CH2:22][C:23]1[N:27]([CH3:28])[CH:26]=[N:25][CH:24]=1)=[O:19]

参加物

4

反応物 1

HCID 86693977HCID 86693977、化合物

生成物 1

HCID 86693978(2S,5R)-6-hydroxy-N-[(1-methyl-1H-imidazol-5-yl)methoxy]-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide収率 79%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of (2S,5R)-6-(benzyloxy)-N-[(1-methyl-1H-imidazol-5-yl)methoxy]-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 101 (0.40 g, 0.90 mmol) and Pd/C (0.13 g) in methanol (20 mL) was hydrogenated at 1 atm at room temperature for 3 h. The mixture was filtered through Celite pad and concentrated to give a residue which was subjected to chromatography to give 102 (0.21 g, 75%) as a white foam.

後処理

  1. filtrationThe mixture was filtered through Celite pad
  2. concentrationconcentrated
  3. customto give a residue which

出典と根拠

ORDレコード
ord-cc3a46778cc44341967eb8b37b3643e7
出典データセット
uspto-grants-2014_08
特許番号
US08796257B2

反応ノート

読み込み中…