HCID 86694092、化合物 → HCID 86694094、化合物

HRID 2400751ノート

反応式

HRID 2400751 の反応式
C([O:8][N:9]1[C:15](=[O:16])[N:14]2[CH2:17][C@H:10]1[CH2:11][CH2:12][C@H:13]2[C:18]([NH:20][NH:21][C:22]([CH:24]1[CH2:27][C:26]([F:29])([F:28])[CH2:25]1)=[O:23])=[O:19])C1C=CC=CC=1.[H][H]>CO.[Pd]>[F:29][C:26]1([F:28])[CH2:27][CH:24]([C:22]([NH:21][NH:20][C:18]([C@@H:13]2[CH2:12][CH2:11][C@@H:10]3[CH2:17][N:14]2[C:15](=[O:16])[N:9]3[OH:8])=[O:19])=[O:23])[CH2:25]1

参加物

5

反応物 2

HCID 86694092HCID 86694092、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 86694094HCID 86694094、化合物収率 96.2%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of (2S,5R)-6-(benzyloxy)-N′-[(3,3-difluorocyclobutyl)carbonyl]-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carbohydrazide 283 (0.32 g, 0.78 mml) in methanol (25 mL) was added 10% Pd/C (0.40 g). The mixture was hydrogenated under 10 psi hydrogen atmosphere at room temperature for 1 h. The catalyst was filtered out through Celite, and the filtrate was evaporated to give 284 (0.24 g, 96%) as a white foam.

後処理

  1. filtrationThe catalyst was filtered out through Celite
  2. customthe filtrate was evaporated

出典と根拠

ORDレコード
ord-e2a0bd453fcf4892af608f2ff37c63ce
出典データセット
uspto-grants-2014_08
特許番号
US08796257B2

反応ノート

読み込み中…