Water → 5-bromo-6-(phenylthio)-2-(1H-pyrazol-1-yl)pyrimidin-4-amine

HRID 2401166

反応式

HRID 2401166 の反応式
[Br:1][C:2]1[C:3]([NH2:14])=[N:4][C:5]([N:9]2[CH:13]=[CH:12][CH:11]=[N:10]2)=[N:6][C:7]=1Cl.[C:15]1([SH:21])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.C([O-])([O-])=O.[Cs+].[Cs+].O>C1COCC1>[Br:1][C:2]1[C:3]([NH2:14])=[N:4][C:5]([N:9]2[CH:13]=[CH:12][CH:11]=[N:10]2)=[N:6][C:7]=1[S:21][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

参加物

6

反応物 4

HCID 962WaterHCID 7969ThiophenolHCID 10796Cesium carbonateHCID 866770175-bromo-6-chloro-2-(1H-pyrazol-1-yl)pyrimidin-4-amine2 回

生成物 1

HCID 574072415-bromo-6-(phenylthio)-2-(1H-pyrazol-1-yl)pyrimidin-4-amine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 0.1 g (0.36 mmol) of 5-bromo-6-chloro-2-(1H-pyrazol-1-yl)pyrimidin-4-amine (Intermediate 5) in 4 ml of THF, 74 μl (0.73 mmol) of thiophenol and 0.178 g (0.55 mmol) of Cs2CO3 were added. The mixture was allowed to react under microwave conditions 15 min. at 100° C. Afterwards the reaction mixture was put on 10 ml of cool water. The formed white precipitate was filtered, washed several times with cold water and dried.

後処理

  1. customto react under microwave conditions 15 min. at 100° C
  2. filtrationThe formed white precipitate was filtered
  3. washwashed several times with cold water
  4. customdried

出典と根拠

ORDレコード
ord-3e7636f6b0f44df19073227f73ac74c2
出典データセット
uspto-grants-2014_08
特許番号
US08796284B2

関連ノート

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