Sodium Azide → 5-bromo-2-(1H-pyrazol-1-yl)pyrimidine-4,6-diamine

HRID 2401168

反応式

HRID 2401168 の反応式
[Br:1][C:2]1[C:3]([NH2:14])=[N:4][C:5]([N:9]2[CH:13]=[CH:12][CH:11]=[N:10]2)=[N:6][C:7]=1Cl.[N-:15]=[N+]=[N-].[Na+]>O1CCOCC1>[Br:1][C:2]1[C:3]([NH2:14])=[N:4][C:5]([N:9]2[CH:13]=[CH:12][CH:11]=[N:10]2)=[N:6][C:7]=1[NH2:15]

参加物

4

反応物 2

HCID 33557Sodium AzideHCID 866770175-bromo-6-chloro-2-(1H-pyrazol-1-yl)pyrimidin-4-amine2 回

生成物 1

HCID 534678255-bromo-2-(1H-pyrazol-1-yl)pyrimidine-4,6-diamine

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

A solution of 0.10 g (0.37 mmol) of 5-bromo-6-chloro-2-(1H-pyrazol-1-yl)pyrimidine-4-amine (Intermediate 5) and 0.05 g (0.77 mmol) of sodium azide in dioxane (10 mL) was stirred at 80° C. for 6 h. The solvent was then evaporated, and the residue dissolved in methanol, Pd on charcoal added (10 mg) and hydrogenated for 30 min. The solvent was again evaporated and the residue crystallizes from ethanol.

後処理

  1. customThe solvent was then evaporated
  2. dissolutionthe residue dissolved in methanol
  3. additionPd on charcoal added (10 mg)
  4. customThe solvent was again evaporated
  5. customthe residue crystallizes from ethanol

出典と根拠

ORDレコード
ord-3c2b21ac9b854f46891fa63dd5814f14
出典データセット
uspto-grants-2014_08
特許番号
US08796284B2

関連ノート

読み込み中…