Sodium borohydride → 1-(6-Chloropyrimidin-4-yl)ethanol

HRID 2401190ノート

反応式

HRID 2401190 の反応式
[Cl:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([C:8](=[O:10])[CH3:9])[CH:3]=1.[BH4-].[Na+]>C(O)C>[Cl:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([CH:8]([OH:10])[CH3:9])[CH:3]=1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 722142471-(6-Chloropyrimidin-4-yl)ethan-1-one2 回

生成物 1

HCID 838541011-(6-Chloropyrimidin-4-yl)ethanol収率 79.7%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

1-(6-Chloro-4-pyrimidinyl)ethanone (Intermediate 18A, 1.0 g, 6.39 mmol) was dissolved in ethanol (21 mL), treated with sodium borohydride (0.242 g, 6.39 mmol) and the resulting mixture was stirred at room temperature under argon for 2 hours. The solvent was removed under reduced pressure and the residue was diluted with water and extracted with ethyl acetate (×3). The ethyl acetate layers were combined, dried under magnesium sulfate and evaporated under reduced pressure to give the title compound as a yellow oil (808 mg);

後処理

  1. customThe solvent was removed under reduced pressure
  2. additionthe residue was diluted with water
  3. extractionextracted with ethyl acetate (×3)
  4. customdried under magnesium sulfate
  5. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-e2acdec75d9640a7ac4fac48b35ea0e7
出典データセット
uspto-grants-2014_08
特許番号
US08796283B2

反応ノート

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