Nitric Acid → 1403597-59-0
反応式
[OH:1][C:2]1[C:3]([CH3:11])=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([OH:7])=[O:6].[N+:12]([O-])([OH:14])=[O:13]>OS(O)(=O)=O>[OH:1][C:2]1[C:3]([CH3:11])=[C:4]([CH:8]=[CH:9][C:10]=1[N+:12]([O-:14])=[O:13])[C:5]([OH:7])=[O:6]参加物
4
反応条件
- 温度
- -40 °C
実験手順
To a solution of 3-hydroxy-2-methylbenzoic acid (5.00 g, 25.3 mmol) in concentrated H2SO4 (98%, 10 mL) was added concentrated HNO3 (63%, 10 mL) dropwise. The mixture was stirred at −40° C. for 10 min. The mixture was poured into ice-water and extracted by EA (3 times). The organic layers were combined, dried over anhydrous Na2SO4. Then the solvent was evaporated in vacuo to afford 3-hydroxy-2-methyl-4-nitrobenzoic acid as a yellow solid, which was used for next step without further purification.
後処理
- extractionextracted by EA (3 times)
- dry with materialdried over anhydrous Na2SO4
- customThen the solvent was evaporated in vacuo
出典と根拠
- ORDレコード
- ord-5a15163921364db49cda624524892cd1
- 出典データセット
- uspto-grants-2014_08
- 特許番号
- US08796296B2
反応ノート
読み込み中…