HCID 86687928、化合物 → HCID 86687929、化合物
反応式
[CH3:1][O:2][C:3]1[C:11]([N+:12]([O-])=O)=[CH:10][CH:9]=[C:8]2[C:4]=1[CH2:5][N:6]([CH3:16])[C:7]2=[O:15]>CO.[Pd]>[NH2:12][C:11]1[C:3]([O:2][CH3:1])=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:15])[N:6]([CH3:16])[CH2:5]2参加物
4
反応条件
- 温度
- 50 °C
実験手順
To a solution of 4-methoxy-2-methyl-5-nitroisoindolin-1-one (155 mg, 0.7 mmol) in MeOH (10 mL) was added Pd/C (60 mg). The mixture was stirred at 50° C. under H2 for 6 h. The resulting suspension was filtered. The filtrate was concentrated under reduced pressure to afford 5-amino-4-methoxy-2-methylisoindolin-1-one (70 mg, yield 52%). m/z (ES+APCI)+: [M+H]+193.1.
後処理
- filtrationThe resulting suspension was filtered
- concentrationThe filtrate was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-07c906a1c0b54aa19a8d7a73999ed3bf
- 出典データセット
- uspto-grants-2014_08
- 特許番号
- US08796296B2
反応ノート
読み込み中…