Methanol → 3-methoxy-9-oxo-9H-indeno[1,2-b]pyrazine-2-carbonitrile

HRID 240306

反応式

HRID 240306 の反応式
[O:1]=[C:2]1[C:14]2[C:9](=[N:10][C:11](C#N)=[C:12]([C:15]#[N:16])[N:13]=2)[C:8]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]1=2.[CH3:19][OH:20]>>[CH3:19][O:20][C:11]1[N:10]=[C:9]2[C:8]3[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=3[C:2](=[O:1])[C:14]2=[N:13][C:12]=1[C:15]#[N:16]

参加物

3

反応物 2

HCID 887MethanolHCID 2929299-oxo-9H-indeno(1,2-b)pyrazine-2,3-dicarbonitrile

生成物 1

HCID 160653533-methoxy-9-oxo-9H-indeno[1,2-b]pyrazine-2-carbonitrile収率 126.5%

実験手順

To a suspension of 1 (1.10 g, 4.7 mmol) in MeOH (47 ml) sodium (110 mg) was added and the mixture was stirred at room temperature for 16 hours. The precipitate was filtered, washed with EtOH and dried under vacuum, yielding 3 (1.03 g, 93%) as yellow-green solid.

後処理

  1. additionwas added
  2. filtrationThe precipitate was filtered
  3. washwashed with EtOH
  4. customdried under vacuum

出典と根拠

ORDレコード
ord-b40012b19977406f87d5a10b4b6e4989
出典データセット
uspto-grants-2014_02
特許番号
US08648076B2

関連ノート

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