Sodium Sulfate → HCID 16065357、化合物

HRID 240308

反応式

HRID 240308 の反応式
[O:1]=[C:2]1[C:14]2[C:9](=[N:10][C:11](C#N)=[C:12]([C:15]#[N:16])[N:13]=2)[C:8]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]1=2.C([O-])(=O)C.[NH4+:23].[O-]S([O-])(=O)=O.[Na+].[Na+]>C1COCC1>[NH2:23][C:11]1[N:10]=[C:9]2[C:8]3[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=3[C:2](=[O:1])[C:14]2=[N:13][C:12]=1[C:15]#[N:16]

参加物

5

反応物 3

HCID 24436Sodium SulfateHCID 2929299-oxo-9H-indeno(1,2-b)pyrazine-2,3-dicarbonitrileHCID 517165Ammonium Acetate

生成物 1

HCID 16065357HCID 16065357、化合物収率 90%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
70 °C

実験手順

A mixture of 1 (201 mg, 0.86 mmol), ammonium acetate (331 mg, 4.3 mmol) and Na2SO4 (200 mg) in THF (2.9 ml) was stirred at 70° C. in sealed tube for 18 hours. The solvent was evaporated, water (5 ml) was added and the precipitate filtered, washed with water and dried under vacuum, affording 7 (171 mg, 90%) as green solid.

後処理

  1. customThe solvent was evaporated
  2. additionwater (5 ml) was added
  3. filtrationthe precipitate filtered
  4. washwashed with water
  5. customdried under vacuum

出典と根拠

ORDレコード
ord-cbcbdab1543444ab9d69875510961707
出典データセット
uspto-grants-2014_02
特許番号
US08648076B2

関連ノート

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