Water → N-(Bromoacetyl)glycine, ethyl ester
反応式
Cl.[CH2:2]([O:4][C:5](=[O:8])[CH2:6][NH2:7])[CH3:3].C([O-])([O-])=O.[K+].[K+].[Br:15][CH2:16][C:17](Br)=[O:18].O>C(Cl)Cl>[CH2:2]([O:4][C:5](=[O:8])[CH2:6][NH:7][C:17](=[O:18])[CH2:16][Br:15])[CH3:3]参加物
6
実験手順
To a mixture of glycine ethyl ester hydrochloride (2.0 g, 14.3 mmol) and K2CO3 (2.1 g, 15.2 mmol) in CH2Cl2 (35 ml) cooled at 0-5° C. bromoacetyl bromide (1.36 ml, 15.6 mmol) was added dropwise. The suspension was stirred at room temperature and after 3 h H2O (20 ml) was added. The phases were separated and the organic one was washed with a saturated solution of NaHCO3 (20 ml) and H2O (20 ml) and dried over Na2SO4. The solvent was evaporated obtaining 39 as white solid (1.2 g, 40%). ESI+MS: calcd for C6H10BrNO3: 224.06; found: 224.0 and 226.0 (MH+).
後処理
- additionwas added dropwise
- additionwas added
- customThe phases were separated
- washthe organic one was washed with a saturated solution of NaHCO3 (20 ml) and H2O (20 ml)
- dry with materialdried over Na2SO4
- customThe solvent was evaporated
出典と根拠
- ORDレコード
- ord-85f3c0cf834d41b9a0e7d9c94b7c9c19
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08648076B2
反応ノート
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