HCID 56834611、化合物 → 4-(Cyclopropylsulfonyl)benzenamine
反応式
[CH:1]1([S:4]([C:7]2[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[CH:9][CH:8]=2)(=[O:6])=[O:5])[CH2:3][CH2:2]1>C(O)C.C1COCC1.[Ni]>[CH:1]1([S:4]([C:7]2[CH:12]=[CH:11][C:10]([NH2:13])=[CH:9][CH:8]=2)(=[O:6])=[O:5])[CH2:3][CH2:2]1参加物
5
実験手順
A solution of 1.60 g (7.0 mmol) of 1-cyclopropanesulphonyl-4-nitrobenzene in 50 ml of ethanol and 50 ml of THF was admixed with 3.2 g of Raney nickel (50% moisture) and hydrogenated for 1.5 hours under atmospheric pressure at 0° C. The mixture was filtered and concentrated by evaporation. This gave 1.28 g (6.5 mmol; yield: 92%) of the product.
後処理
- filtrationThe mixture was filtered
- concentrationconcentrated by evaporation
出典と根拠
- ORDレコード
- ord-816d1729edc7439796008f0fea176320
- 出典データセット
- uspto-grants-2014_08
- 特許番号
- US08802686B2
反応ノート
読み込み中…