Iodoethane → 2-(1-Ethylpiperidin-4-yl)ethan-1-ol

HRID 2403794ノート

反応式

HRID 2403794 の反応式
[NH:1]1[CH2:6][CH2:5][CH:4]([CH2:7][CH2:8][OH:9])[CH2:3][CH2:2]1.C(=O)([O-])[O-].[K+].[K+].I[CH2:17][CH3:18]>CN(C=O)C>[CH2:17]([N:1]1[CH2:6][CH2:5][CH:4]([CH2:7][CH2:8][OH:9])[CH2:3][CH2:2]1)[CH3:18]

参加物

5

反応物 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 739534-Piperidineethanol

生成物 1

HCID 217027812-(1-Ethylpiperidin-4-yl)ethan-1-ol

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a stirring solution of 2-(4-piperidinyl)ethanol (Ig, 7.74 mmol) and potassium carbonate (2.67 g, 19.35 mmol) in dry DMF (10 ml) was added iodoethane (0.687 ml, 8.51 mmol). The reaction mixture was allowed to stir at room temperature for 18 hours. The solvent was partially removed in vacuo and the residue partitioned between water (20 ml) and ethyl acetate (20 ml). The aqueous was washed with further ethyl acetate and the combined organics dried (hydrophobic frit) and concentrated in vacuo to give the title compound as a mixture with residual DMF as a clear oil, 1.55 g

後処理

  1. customThe solvent was partially removed in vacuo
  2. customthe residue partitioned between water (20 ml) and ethyl acetate (20 ml)
  3. washThe aqueous was washed with further ethyl acetate
  4. customthe combined organics dried (hydrophobic frit)
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-3a90a7ce2fcf4602aeab94ba7a38f11f
出典データセット
uspto-grants-2014_08
特許番号
US08802684B2

反応ノート

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