Iodoethane → 9-[(1-Ethyl-4-piperidinyl)methyl]-2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-6-amine

HRID 2403845ノート

反応式

HRID 2403845 の反応式
[CH2:1]([N:3]1[CH2:8][CH2:7]C[CH:5]([CH2:9][CH2:10][N:11]2[C:19]([O:20][CH3:21])=[N:18][C:17]3[C:12]2=[N:13][C:14]([O:23][C@@H:24]([CH3:28])[CH2:25][CH2:26][CH3:27])=[N:15][C:16]=3[NH2:22])[CH2:4]1)[CH3:2].C[C@H](OC1N=C2C(N=C(OC)N2CC2CCNCC2)=C(N)N=1)CCC.ICC>>[CH2:1]([N:3]1[CH2:4][CH2:5][CH:9]([CH2:10][N:11]2[C:19]([O:20][CH3:21])=[N:18][C:17]3[C:12]2=[N:13][C:14]([O:23][C@@H:24]([CH3:28])[CH2:25][CH2:26][CH3:27])=[N:15][C:16]=3[NH2:22])[CH2:7][CH2:8]1)[CH3:2]

参加物

4

反応物 3

HCID 6340IodoethaneHCID 583062129-[2-(1-Ethyl-3-piperidinyl)ethyl]-2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-6-amineHCID 583062582-{[(1S)-1-Methylbutyl]oxy}-8-(methyloxy)-9-(4-piperidinylmethyl)-9H-purin-6-amine

生成物 1

HCID 583060839-[(1-Ethyl-4-piperidinyl)methyl]-2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-6-amine

実験手順

Prepared similarly to Intermediate 46 from 2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9-(4-piperidinylmethyl)-9H-purin-6-amine and iodoethane.

出典と根拠

ORDレコード
ord-d93df279431c4892a8ba837f4b1a25f6
出典データセット
uspto-grants-2014_08
特許番号
US08802684B2

反応ノート

読み込み中…