Water → HCID 68313699、化合物
反応式
[F:1][C:2]1[C:3]([N+:16]([O-])=O)=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[N:7][C:6]([CH2:12][CH:13]([CH3:15])[CH3:14])=[CH:5]2.O>C1COCC1.[Ni]>[F:1][C:2]1[CH:11]=[CH:10][C:9]2[CH:8]=[N:7][C:6]([CH2:12][CH:13]([CH3:14])[CH3:15])=[CH:5][C:4]=2[C:3]=1[NH2:16]参加物
5
実験手順
A solution of Example 139B (2.39 g, 9.63 mmol) in THF (50 mL) was added to a Ra—Ni 2800, water slurry (2.390 g, 40.7 mmol) in a 250 mL pressure bottle and stirred for 100 min at 30 psi and ambient temperature. The mixture was filtered through a nylon membrane and then concentrated under reduced pressure to provide the title compound (2.15 g, 100% yield), which was used without further purification. (ESI) m/z 219.2 (M+H)+.
後処理
- filtrationThe mixture was filtered through a nylon membrane
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-ec7dca3b43d0456dae4b3567beab28b2
- 出典データセット
- uspto-grants-2014_08
- 特許番号
- US08802711B2
反応ノート
読み込み中…