4-Chloro-2-isocyanato-1-methoxybenzene → 1-(5-chloro-2-methoxyphenyl)-3-(1H-indol-4-yl)urea

HRID 240469

反応式

HRID 240469 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:11][CH3:12])=[C:6]([N:8]=[C:9]=[O:10])[CH:7]=1.[NH2:13][C:14]1[CH:22]=[CH:21][CH:20]=[C:19]2[C:15]=1[CH:16]=[CH:17][NH:18]2>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:11][CH3:12])=[C:6]([NH:8][C:9]([NH:13][C:14]2[CH:22]=[CH:21][CH:20]=[C:19]3[C:15]=2[CH:16]=[CH:17][NH:18]3)=[O:10])[CH:7]=1

参加物

4

反応物 2

HCID 1440094-Chloro-2-isocyanato-1-methoxybenzeneHCID 5834314-Aminoindole

生成物 1

HCID 666135101-(5-chloro-2-methoxyphenyl)-3-(1H-indol-4-yl)urea収率 70%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

A solution of 5-chloro-2-methoxyphenyl isocyanate (Int-4, 5.5 g, 30 mmol) in DCM (20 mL) was added dropwise to the 4-amino-1H-indole in DCM (30 mL) from Step A, and the resulting mixture was stirred overnight, then filtered to give the crude product 1-(5-chloro-2-methoxyphenyl)-3-(1H-indol-4-yl)urea (6.6 g, 70%), which was used directly in the next step without purification.

後処理

  1. filtrationfiltered

出典と根拠

ORDレコード
ord-de54c33bb23a4aabacae83b75d98320b
出典データセット
uspto-grants-2014_02
特許番号
US08648086B2

関連ノート

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