HCID 73110260、化合物 → (3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-ol
反応式
[CH3:1][C:2]1([CH3:12])[O:10][CH:9]2[CH:4]([CH:5]3[CH2:11][CH:8]2[O:7][NH:6]3)[O:3]1>[Pd].CO>[NH2:6][C@H:5]1[C@@H:4]2[O:3][C:2]([CH3:1])([CH3:12])[O:10][C@@H:9]2[C@@H:8]([OH:7])[CH2:11]1参加物
4
反応条件
- 温度
- 20 °C
実験手順
Under a pressurized hydrogen atmosphere (3 atm), a suspension of 4,4-dimethyl-3,5,8-trioxa-9-aza-tricyclo[5.2.1.02,6]decane (16.7 g, 97.55 mmol, 1.00 equiv.), 10% palladium on carbon (1.67 g), and methanol (250 mL) was stirred at about 20° C. for about 60 minutes. After filtering the solution, the resulting filtrate was concentrated in vacuo to give the title product as a white solid (16.8 g; yield=99%). MS: m/z=174 (MH)+.
後処理
- filtrationAfter filtering the solution
- concentrationthe resulting filtrate was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-4a59a90a89fb4f73be2c5358d53f18bd
- 出典データセット
- uspto-grants-2014_08
- 特許番号
- US08802850B2
反応ノート
読み込み中…