Hydrochloric Acid → 4-(Carboxymethoxy)benzoic acid

HRID 2405188ノート

反応式

HRID 2405188 の反応式
C[O:2][C:3](=[O:16])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][C:12]([O:14]C)=[O:13])=[CH:6][CH:5]=1.[OH-].[Na+].Cl>O>[C:12]([CH2:11][O:10][C:7]1[CH:8]=[CH:9][C:4]([C:3]([OH:16])=[O:2])=[CH:5][CH:6]=1)([OH:14])=[O:13]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 887006methyl 4-(2-methoxy-2-oxoethoxy)benzoate

生成物 1

HCID 880244-(Carboxymethoxy)benzoic acid収率 91.4%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

4-Methoxycarbonylmethoxy-benzoic acid methyl ester 1 (50 grams, 223 mmol) was added to a solution of 2.5 M sodium hydroxide (250 mL) and heated to 80° C. for 5 hours. The reaction mixture was dilated with water (100 mL) and pH adjusted to 1 with concentrated HCl. Crude 76 was filtered, dried and given hot ethyl acetate slurry to give 76 (40 grams, 91.4%) as a white powder. M.p: >280° C.

後処理

  1. filtrationCrude 76 was filtered
  2. customdried

出典と根拠

ORDレコード
ord-cc01f91bedae4e3daac2497c047e641f
出典データセット
uspto-grants-2014_08
特許番号
US08802892B2

反応ノート

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