1,1-Dimethylethyl (3aS,6aS)-hexahydropyrrolo[3,4-b]pyrrole-1(2H)-carboxylate → (3aS,6aS)-tert-butyl 5-(5-(3,5-difluorophenylcarbamoyl)pyridin-3-yl)hexahydropyrrolo[2,3-c]pyrrole-1(2H)-carboxylate

HRID 240528

反応式

HRID 240528 の反応式
Br[C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:18]=1)[C:7]([NH:9][C:10]1[CH:15]=[C:14]([F:16])[CH:13]=[C:12]([F:17])[CH:11]=1)=[O:8].[N:19]1([C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[CH2:23][CH2:22][C@H:21]2[CH2:24][NH:25][CH2:26][C@@H:20]12>>[F:17][C:12]1[CH:11]=[C:10]([NH:9][C:7]([C:6]2[CH:18]=[C:2]([N:25]3[CH2:24][C@@H:21]4[CH2:22][CH2:23][N:19]([C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[C@@H:20]4[CH2:26]3)[CH:3]=[N:4][CH:5]=2)=[O:8])[CH:15]=[C:14]([F:16])[CH:13]=1

参加物

3

反応物 2

HCID 299490891,1-Dimethylethyl (3aS,6aS)-hexahydropyrrolo[3,4-b]pyrrole-1(2H)-carboxylateHCID 416011495-bromo-N-(3,5-difluorophenyl)nicotinamide

生成物 1

HCID 67265843(3aS,6aS)-tert-butyl 5-(5-(3,5-difluorophenylcarbamoyl)pyridin-3-yl)hexahydropyrrolo[2,3-c]pyrrole-1(2H)-carboxylate

実験手順

The product from Example 53A and (3aS,6aS)-tert-butyl hexahydropyrrolo[3,4-b]pyrrole-1(2H)-carboxylate (prepared as described in WO2001081347) were processed as described in Example 53B to provide the title compound. MS (APCI) m/z=445 (M+H)+.

出典と根拠

ORDレコード
ord-675ac849444c474f85b701a72f53dd1d
出典データセット
uspto-grants-2014_02
特許番号
US08648084B2

関連ノート

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