Ethanol → Tert-butyl 4-(benzyloxy)pyridin-2-ylcarbamate

反応式

[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]([NH2:15])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:16]([OH:18])C.[CH3:19][C:20]([OH:23])([CH3:22])[CH3:21]>>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]([NH:15][C:16](=[O:18])[O:23][C:20]([CH3:22])([CH3:21])[CH3:19])[CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

反応物 3

HCID 702Ethanol

HCID 6386tert-Butanol

HCID 5200844-(Benzyloxy)pyridin-2-amine

生成物 1

HCID 66937350Tert-butyl 4-(benzyloxy)pyridin-2-ylcarbamate収率 85%

反応条件

温度: 50 °C

実験手順

To a solution of 4-(benzyloxy)pyridin-2-amine (4.6 g, 22.97 mmol) in tBuOH (50 mL) was added boc-anhydride (5.57 g, 25.5 mmol). After heating to 50° C. for 1 hour, ethanol (200 mL) was added to the reaction mixture. The room temperature mixture was filtered to provide the solid product (5.89 g, 85%).