N-methyl-4-(2-methyl-4-nitrophenoxy)-2-nitrobenzenamine → 4-(4-amino-2-methylphenoxy)-N1-methylbenzene-1,2-diamine

HRID 240558

反応式

HRID 240558 の反応式
[CH3:1][NH:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][C:10]2[CH:15]=[CH:14][C:13]([N+:16]([O-])=O)=[CH:12][C:11]=2[CH3:19])=[CH:5][C:4]=1[N+:20]([O-])=O.[H][H]>C(OCC)(=O)C.C(O)C.[Pd]>[NH2:16][C:13]1[CH:14]=[CH:15][C:10]([O:9][C:6]2[CH:5]=[C:4]([NH2:20])[C:3]([NH:2][CH3:1])=[CH:8][CH:7]=2)=[C:11]([CH3:19])[CH:12]=1

参加物

6

反応物 2

HCID 86650896N-methyl-4-(2-methyl-4-nitrophenoxy)-2-nitrobenzenamineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 669371924-(4-amino-2-methylphenoxy)-N1-methylbenzene-1,2-diamine

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 702Ethanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of N-methyl-4-(2-methyl-4-nitrophenoxy)-2-nitrobenzenamine (1.90 g, 6.27 mmol) in ethyl acetate (10 mL) and ethanol (20 mL) was added 10% Pd/C (0.342 g, 0.321 mmol). After shaking under 50 psi of hydrogen for 1 hour, the mixture was filtered and the filtrate was concentrated under reduced pressure to provide the product as clear oil.

後処理

  1. filtrationthe mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-9235edec2efb4c5786933c8050ce5fc7
出典データセット
uspto-grants-2014_02
特許番号
US08648087B2

関連ノート

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