Formamide → HCID 178518013、化合物

HRID 240571

反応式

HRID 240571 の反応式
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([I:11])=[CH:7][C:3]=1[C:4](O)=[O:5].[CH:12]([NH2:14])=O>O>[I:11][C:8]1[CH:7]=[C:3]2[C:2](=[CH:10][CH:9]=1)[N:1]=[CH:12][N:14]=[C:4]2[OH:5]

参加物

4

反応物 2

HCID 713FormamideHCID 72911Benzoic acid, 2-amino-5-iodo-

生成物 1

HCID 178518013HCID 178518013、化合物収率 83%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
190 °C

実験手順

A mixture of 2-amino-5-iodobenzoic acid (125 g, 475 mmol) and formamide (200 mL) was heated to 190° C. for 2 hours. After cooling to room temperature, the reaction mixture was poured into water (500 mL) and stirred for 2 hours. The solids were filtered and dried under high vacuum to provide the product (108 g, 83%).

後処理

  1. temperatureAfter cooling to room temperature
  2. filtrationThe solids were filtered
  3. customdried under high vacuum

出典と根拠

ORDレコード
ord-1cf203d6a8f34d2ea4d9ba40e1884b22
出典データセット
uspto-grants-2014_02
特許番号
US08648087B2

関連ノート

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