Trifluoroacetic acid → 4-([1,2,4]Triazolo[1,5-a]pyridin-7-yloxy)-3-chloro-2-fluorobenzoic acid
反応式
[N:1]1[CH:2]=[N:3][N:4]2[CH:9]=[CH:8][C:7]([O:10][C:11]3[CH:23]=[CH:22][C:14]([C:15]([O:17]C(C)(C)C)=[O:16])=[C:13]([F:24])[C:12]=3[Cl:25])=[CH:6][C:5]=12.FC(F)(F)C(O)=O>ClCCl>[N:1]1[CH:2]=[N:3][N:4]2[CH:9]=[CH:8][C:7]([O:10][C:11]3[CH:23]=[CH:22][C:14]([C:15]([OH:17])=[O:16])=[C:13]([F:24])[C:12]=3[Cl:25])=[CH:6][C:5]=12参加物
4
反応条件
- 温度
- 0 °C
実験手順
A 25 ml flask was charged with tert-butyl 4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-chloro-2-fluorobenzoate (0.060 g, 0.16 mmol) and dichloromethane (1.6 ml). The reaction was cooled to 0° C., and 2,2,2-trifluoroacetic acid (0.50 ml, 0.16 mmol) was added. The reaction was stirred for 20 minutes, then warmed to ambient temperature, stirred an additional 3 hours, and then concentrated to provide the desired product as a colorless oily residue.