(S)-tert-butyl 3-(5-fluoro-2-nitrophenoxy)piperidine-1-carboxylate → (S)-tert-butyl 3-(2-amino-5-fluorophenoxy)piperidine-1-carboxylate

HRID 240594ノート

反応式

HRID 240594 の反応式
[F:1][C:2]1[CH:3]=[CH:4][C:5]([N+:22]([O-])=O)=[C:6]([CH:21]=1)[O:7][C@H:8]1[CH2:13][CH2:12][CH2:11][N:10]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:9]1>CO.[Pd]>[NH2:22][C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:21][C:6]=1[O:7][C@H:8]1[CH2:13][CH2:12][CH2:11][N:10]([C:14]([O:16][C:17]([CH3:19])([CH3:20])[CH3:18])=[O:15])[CH2:9]1

参加物

4

反応物 1

HCID 58413048(S)-tert-butyl 3-(5-fluoro-2-nitrophenoxy)piperidine-1-carboxylate

生成物 1

HCID 58413089(S)-tert-butyl 3-(2-amino-5-fluorophenoxy)piperidine-1-carboxylate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of (S)-tert-butyl 3-(5-fluoro-2-nitrophenoxy)piperidine-1-carboxylate (6.41 g) in MeOH (70.0 ml) was added palladium on charcoal (600.0 mg), the mixture hydrogenated at room temperature and 50 psi. The catalyst was filtered off and the filtrate was concentrated under reduced pressure. The residue was purified by silica chromatography to give the desired product.

後処理

  1. customhydrogenated at room temperature
  2. filtrationThe catalyst was filtered off
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customThe residue was purified by silica chromatography

出典と根拠

ORDレコード
ord-88c079872f0242228e04ee046c9b1af7
出典データセット
uspto-grants-2014_02
特許番号
US08648068B2

反応ノート

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