Methyl iodide → 5-Chloro-2-heptyl-1-methyl-1H-indole
反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])=[CH:5]2.[OH-].[K+].I[CH3:21]>CS(C)=O>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:21])[C:6]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])=[CH:5]2参加物
5
実験手順
To the solution of 5-chloro-2-heptyl-1H-indole in DMSO was added KOH at RT and was stirred for 30 minutes. Then to this mixture, iodomethane was added and stirred for 3 hours. The reaction was quenched with saturated ammonium chloride solution and extracted with ethyl acetate. The product, 5-chloro-2-heptyl-1-methyl-1H-indole was purified by column chromatography.
後処理
- stirringstirred for 3 hours
- customThe reaction was quenched with saturated ammonium chloride solution
- extractionextracted with ethyl acetate
- customThe product, 5-chloro-2-heptyl-1-methyl-1H-indole was purified by column chromatography
出典と根拠
- ORDレコード
- ord-baac91965f8145faa0e5077a0881266a
- 出典データセット
- uspto-grants-2014_08
- 特許番号
- US08809382B2
反応ノート
読み込み中…