Trifluoroacetic acid → 4-(2-((Tert-butyldimethylsilyl)oxy)ethyl)piperidin-1-amine 2,2,2-trifluoroacetate
反応式
C(OC(=O)[NH:7][N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][CH2:15][O:16][Si:17]([C:20]([CH3:23])([CH3:22])[CH3:21])([CH3:19])[CH3:18])[CH2:10][CH2:9]1)(C)(C)C.[F:25][C:26]([F:31])([F:30])[C:27]([OH:29])=[O:28]>ClCCl>[F:25][C:26]([F:31])([F:30])[C:27]([OH:29])=[O:28].[C:20]([Si:17]([CH3:19])([CH3:18])[O:16][CH2:15][CH2:14][CH:11]1[CH2:12][CH2:13][N:8]([NH2:7])[CH2:9][CH2:10]1)([CH3:22])([CH3:21])[CH3:23]参加物
4
反応条件
- 温度
- 0 °C
実験手順
{4-[2-(t-Butyl-dimethyl-silanyloxy)-ethyl]-piperidin-1-yl}-carbamic acid t-butyl ester (168 mg, 468 μmol) was at 0° C. combined with dichloromethane (2 mL) and trifluoroacetic acid (2 mL) to give a light yellow solution. The reaction mixture was stirred for 2 h at 0° C. and subsequently concentrated in vacuo to give the title compound as yellow oil, which was used without further purification in the next step.