Pyridine → HCID 178441436、化合物

HRID 2407199

反応式

HRID 2407199 の反応式
[CH2:1]([C:8]1[C:9]([NH:21][CH:22]([CH2:26][CH2:27][CH2:28][CH3:29])[C:23](O)=[O:24])=[N:10][CH:11]=[C:12]([C:14]2[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=2)[N:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.N1C=CC=CC=1.C1(N=C=NC2CCCCC2)CCCCC1>C(Cl)Cl>[CH2:1]([C:8]1[NH:13][C:12]([C:14]2[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=2)=[CH:11][N:10]2[C:23](=[O:24])[C:22]([CH2:26][CH2:27][CH2:28][CH3:29])=[N:21][C:9]=12)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 1049PyridineHCID 10868DicyclohexylcarbodiimideHCID 1363910342-((3-Benzyl-5-(4-hydroxyphenyl)pyrazin-2-yl)amino)hexanoic acid

生成物 1

HCID 178441436HCID 178441436、化合物収率 89.3%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

2-((3-benzyl-5-(4-hydroxyphenyl)pyrazin-2-yl)amino)hexanoic acid (130 mg, 0.33 mmol) was dissolved in DCM (10 mL). Pyridine (0.5 mL) was added followed by N,N′-Dicyclohexylcarbodiimide (137 mg, 0.67 mmol). The reaction mixture was slowly stirred at room temperature for 1 hr. The solvent was evaporated, and the residue purified by flash chromatography (eluting solvent: EtOAc to DCM to 10% methanol in DCM) to give the product as a yellow powder (110 mg, 89%). 1H NMR (300 MHz, CD3OD, δ): 7.30 (m, 8H), 6.88 (d, 2H), 4.40 (s, 2H), 2.84 (t, 2H), 1.77 (m, 2H), 1.51 (m, 2H), 0.89 (m, 3H); MS (ESI) m/z 374.3 (M+1).

後処理

  1. customThe solvent was evaporated
  2. customthe residue purified by flash chromatography (eluting solvent: EtOAc to DCM to 10% methanol in DCM)

出典と根拠

ORDレコード
ord-c2fa461598f34e8ea58fa3d9af4af412
出典データセット
uspto-grants-2014_08
特許番号
US08809529B2

関連ノート

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