Methyl 1-(5-bromopyridin-3-yl)cyclopropanecarboxylate → HCID 66788306、化合物
反応式
[Br:1][C:2]1[CH:3]=[C:4]([C:8]2([C:11]([O:13]C)=[O:12])[CH2:10][CH2:9]2)[CH:5]=[N:6][CH:7]=1.O([Si](C)(C)C)[K:16]>C1COCC1>[Br:1][C:2]1[CH:3]=[C:4]([C:8]2([C:11]([O-:13])=[O:12])[CH2:9][CH2:10]2)[CH:5]=[N:6][CH:7]=1.[K+:16]参加物
4
実験手順
To a solution of methyl 1-(5-bromopyridin-3-yl)cyclopropanecarboxylate (1 g, 3.9 mmol) in THF (40 mL) was added 90% KOTMS (0.557 g, 3.9 mmol), and the mixture was stirred at room temperature overnight. The mixture was filtered and washed with THF to give potassium 1-(5-bromopyridin-3-yl)cyclopropanecarboxylate. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.63-0.69 (m, 2H), 1.09-1.15 (m, 2H), 7.79-7.80 (m, 1H), 8.34-8.37 (m, 2H).
後処理
- filtrationThe mixture was filtered
- washwashed with THF
出典と根拠
- ORDレコード
- ord-d53acf07f0f24ca69bbe048d2ad1c7d4
- 出典データセット
- uspto-grants-2014_08
- 特許番号
- US08809545B2
反応ノート
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