Sodium Hydroxide → 2,3-dihydro-2,2-diMethylbenzofuran-5-carboxylic acid

HRID 2407474ノート

反応式

HRID 2407474 の反応式
[OH-].[Na+].C([O:5][C:6]([C:8]1[CH:9]=[CH:10][C:11]2[O:15][C:14]([CH3:17])([CH3:16])[CH2:13][C:12]=2[CH:18]=1)=[O:7])C>>[CH3:16][C:14]1([CH3:17])[CH2:13][C:12]2[CH:18]=[C:8]([C:6]([OH:7])=[O:5])[CH:9]=[CH:10][C:11]=2[O:15]1

参加物

3

反応物 2

HCID 14798Sodium HydroxideHCID 59509487HCID 59509487、化合物

生成物 1

HCID 148382312,3-dihydro-2,2-diMethylbenzofuran-5-carboxylic acid

反応条件

温度
75 °C

実験手順

An aqueous solution (10 mL) of sodium hydroxide (0.78 g, 0.0195 mol) is added to an ethanolic solution (30 mL) of 2,2-dimethyl-2,3-dihydrobenzofuran-5-carboxylic acid ethyl ester (3.9 g, 0.018 mol). The reaction mixture is heated at 75° C. for four and an half hours. Ethanol is removed under reduced pressure. Demineralized water is added to the residue and pH is brought to ˜3 with 1 N HCl. Solid thus obtained is filtered, washed with demineralized water and dried under reduced pressure to give 2,2-dimethyl-2,3-dihydrobenzofuran-5-carboxylic acid.

後処理

  1. customEthanol is removed under reduced pressure
  2. additionDemineralized water is added to the residue and pH
  3. customSolid thus obtained
  4. filtrationis filtered
  5. washwashed with demineralized water
  6. customdried under reduced pressure

出典と根拠

ORDレコード
ord-a00a28ebb39b4582afdeb63a8db86b20
出典データセット
uspto-grants-2014_08
特許番号
US08809539B2

反応ノート

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