Sodium Azide → 4-(azidomethyl)tetrahydro-2H-pyran

HRID 240759

反応式

HRID 240759 の反応式
I[CH2:2][CH:3]1[CH2:8][CH2:7][O:6][CH2:5][CH2:4]1.[N-:9]=[N+:10]=[N-:11].[Na+]>CS(C)=O.C(OCC)C>[N:9]([CH2:2][CH:3]1[CH2:8][CH2:7][O:6][CH2:5][CH2:4]1)=[N+:10]=[N-:11]

参加物

5

反応物 2

HCID 33557Sodium AzideHCID 27955074-(Iodomethyl)oxane

生成物 1

HCID 594860844-(azidomethyl)tetrahydro-2H-pyran

試薬・触媒・溶媒 2

HCID 679Dimethyl Sulfoxide溶媒HCID 3283Diethyl Ether溶媒

実験手順

4-(Iodomethyl)tetrahydro-2H-pyran (4.76 g, 21.1 mmol) was dissolved in dimethyl sulfoxide (25 mL). Sodium azide (2.70 g, 41.5 mmol) was added and the mixture was stirred at ambient temperature overnight. The resulting slurry was diluted with diethyl ether and washed with water. The organic layer was concentrated under reduced pressure to afford the title compound. The product was used directly in subsequent reactions without characterization.

後処理

  1. washwashed with water
  2. concentrationThe organic layer was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-36b0761f4dae4054b34f378061eef753
出典データセット
uspto-grants-2014_02
特許番号
US08648069B2

関連ノート

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