[5-(2-PYRIDINYL)-2-THIENYL]METHANOL → 5-(Pyridin-2-yl)thiophene-2-carbaldehyde

HRID 2407664ノート

反応式

HRID 2407664 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[S:11][C:10]([CH2:12][OH:13])=[CH:9][CH:8]=1>O1CCCC1.[O-2].[O-2].[Mn+4]>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[S:11][C:10]([CH:12]=[O:13])=[CH:9][CH:8]=1

参加物

4

反応物 1

HCID 2776202[5-(2-PYRIDINYL)-2-THIENYL]METHANOL

生成物 1

HCID 6051275-(Pyridin-2-yl)thiophene-2-carbaldehyde収率 8,307.6%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of (5-(pyridin-2-yl)thien-2-yl) methanol (0.100 g) and manganese dioxide (0.136 g) in tetrahydrofuran (3.5 mL) was refluxed overnight. The mixture was cooled to room temperature and the solids were filtered. The filtrate was concentrated and the residue was triturated (hexane:diethyl ether=1:1) to obtain the title compound (8.22 g) having the following physical data.

後処理

  1. filtrationthe solids were filtered
  2. concentrationThe filtrate was concentrated
  3. customthe residue was triturated (hexane:diethyl ether=1:1)

出典と根拠

ORDレコード
ord-27bbdf48b6e240269cf7de43153fb030
出典データセット
uspto-grants-2014_08
特許番号
US08809538B2

反応ノート

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