Sodium Azide → 1-(Azidomethyl)-4-(trifluoromethyl)benzene

HRID 240769ノート

反応式

HRID 240769 の反応式
[N-:1]=[N+:2]=[N-:3].[Na+].[F:5][C:6]([F:16])([F:15])[C:7]1[CH:14]=[CH:13][C:10]([CH2:11]Br)=[CH:9][CH:8]=1>CS(C)=O.C(OCC)(=O)C>[N:1]([CH2:11][C:10]1[CH:9]=[CH:8][C:7]([C:6]([F:5])([F:15])[F:16])=[CH:14][CH:13]=1)=[N+:2]=[N-:3]

参加物

5

反応物 2

HCID 33557Sodium AzideHCID 1230621-(Bromomethyl)-4-(trifluoromethyl)benzene

生成物 1

HCID 498459471-(Azidomethyl)-4-(trifluoromethyl)benzene

試薬・触媒・溶媒 2

HCID 679Dimethyl Sulfoxide溶媒HCID 8857Ethyl Acetate溶媒

実験手順

Sodium azide (2.30 g, 35.4 mmol) was added to a solution of 4-(trifluoromethyl)benzyl bromide (4.26 g, 17.8 mmol) dissolved in dimethyl sulfoxide (15 mL) and stirred at ambient temperature overnight. The mixture was diluted with ethyl acetate, washed with water and brine, and dried over sodium sulfate. After filtration, the solvent was removed under reduced pressure to afford the title compound. The crude product was used in the next step without further characterization.

後処理

  1. washwashed with water and brine
  2. dry with materialdried over sodium sulfate
  3. filtrationAfter filtration
  4. customthe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-c0041892b7b94bc08fcecf4a0763adef
出典データセット
uspto-grants-2014_02
特許番号
US08648069B2

反応ノート

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