Sodium Chloride → HCID 58503970、化合物

HRID 2407792ノート

反応式

HRID 2407792 の反応式
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([O:10][CH2:11][CH3:12])[N:5]=[C:4]([C:13]([NH:15][CH2:16][CH:17]2[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]2)=[O:14])[CH:3]=1.FC(F)(F)C(O)=O.C(=O)(O)[O-].[Na+].[Cl-].[Na+]>ClCCl.C(OCC)(=O)C>[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([O:10][CH2:11][CH3:12])[N:5]=[C:4]([C:13]([NH:15][CH2:16][CH:17]2[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]2)=[O:14])[CH:3]=1

参加物

7

反応物 4

HCID 5234Sodium ChlorideHCID 6422Trifluoroacetic acidHCID 516892Sodium BicarbonateHCID 58504102HCID 58504102、化合物

生成物 1

HCID 58503970HCID 58503970、化合物収率 102.3%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 8857Ethyl Acetate溶媒

実験手順

The compound prepared in Example 225 (3.579 g) was suspended in dichloromethane (50 mL) and trifluoroacetic acid (10.00 mL) added and the reaction mixture stirred at room temperature for 2 hours. The reaction mixture was poured onto saturated aqueous sodium bicarbonate and ethyl acetate. The aqueous layer was saturated with sodium chloride. The desired material crystallized from the aqueous and was isolated by filtration to obtain the title compound (2.752 g) with the following physical data.

後処理

  1. customThe desired material crystallized from the aqueous and
  2. customwas isolated by filtration

出典と根拠

ORDレコード
ord-20ae0b4ed24d4ddbaf96d19cd1481ed5
出典データセット
uspto-grants-2014_08
特許番号
US08809538B2

反応ノート

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