Hydrochloric Acid → 4-Amino-5,6-dichloropicolinic Acid
反応式
[NH2:1][C:2]1[C:7]([Cl:8])=[C:6]([Cl:9])[N:5]=[C:4]([C:10]([O:12]C)=[O:11])[CH:3]=1.C[Si](C)(C)[O-].[K+].Cl.C(OCC)(=O)C>O1CCCC1.O>[NH2:1][C:2]1[C:7]([Cl:8])=[C:6]([Cl:9])[N:5]=[C:4]([C:10]([OH:12])=[O:11])[CH:3]=1参加物
7
実験手順
The compound prepared in Example 405 (2.438 g) and potassium trimethylsilanolate (2.971 g) were suspended in tetrahydrofuran (100 mL) and stirred at reflux for 4 hours. The reaction mixture was dissolved in water and added to 1 N hydrochloric acid. Ethyl acetate was added and the system stirred at room temperature. The organics were dried, magnesium sulfate and concentrated under reduced pressure to furnish the title compound (2.250 g), which was used without further purification, possessing the following physical data.
後処理
- temperatureat reflux for 4 hours
- stirringthe system stirred at room temperature
- customThe organics were dried
- concentrationmagnesium sulfate and concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-2d3e1c67be8e44c29e6804966f15762b
- 出典データセット
- uspto-grants-2014_08
- 特許番号
- US08809538B2
反応ノート
読み込み中…