Trifluoroacetic acid → 4-phenoxy-N-(piperidin-4-ylmethyl)-1H-pyrazolo[4,3-c]pyridin-3-amine bis(2,2,2-trifluoroacetate)

HRID 2407829ノート

反応式

HRID 2407829 の反応式
[O:1]([C:8]1[C:13]2[C:14]([NH:17][CH2:18][CH:19]3[CH2:24][CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21][CH2:20]3)=[N:15][NH:16][C:12]=2[CH:11]=[CH:10][N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:32][C:33]([F:38])([F:37])[C:34]([OH:36])=[O:35]>ClCCl>[F:32][C:33]([F:38])([F:37])[C:34]([OH:36])=[O:35].[F:32][C:33]([F:38])([F:37])[C:34]([OH:36])=[O:35].[O:1]([C:8]1[C:13]2[C:14]([NH:17][CH2:18][CH:19]3[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]3)=[N:15][NH:16][C:12]=2[CH:11]=[CH:10][N:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 58504078HCID 58504078、化合物

生成物 1

HCID 866590634-phenoxy-N-(piperidin-4-ylmethyl)-1H-pyrazolo[4,3-c]pyridin-3-amine bis(2,2,2-trifluoroacetate)

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

A solution of the compound prepared in Example 435 (0.262 g) in dichloromethane (3 mL) was treated with trifluoroacetic acid (0.6 mL) at room temperature. After stirring at room temperature for 4 hours, the mixture was shaken in dichloromethane and washed with aqueous saturated sodium bicarbonate, dried, and evaporated in vacuo to provide the title compound (0.065 g) with the following physical data.

後処理

  1. washwashed with aqueous saturated sodium bicarbonate
  2. customdried
  3. customevaporated in vacuo

出典と根拠

ORDレコード
ord-bdfe6e62e1a64945bd44829c782d3b81
出典データセット
uspto-grants-2014_08
特許番号
US08809538B2

反応ノート

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