5-Aminopyridine-2-carbonitrile → HCID 178510044、化合物

HRID 2408129

反応式

HRID 2408129 の反応式
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]#[N:9])=[N:6][CH:7]=1.[N:10]1([C:16]2[CH:17]=[C:18]([CH:21]=[CH:22][CH:23]=2)[CH:19]=O)[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1>C1(C)C=CC=CC=1.C1(C)C=CC(S(O)(=O)=O)=CC=1>[N:10]1([C:16]2[CH:17]=[C:18](/[CH:19]=[N:1]/[C:2]3[CH:3]=[CH:4][C:5]([C:8]#[N:9])=[N:6][CH:7]=3)[CH:21]=[CH:22][CH:23]=2)[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1

参加物

5

反応物 2

HCID 38713955-Aminopyridine-2-carbonitrileHCID 71645843-Morpholinobenzaldehyde

生成物 1

HCID 178510044HCID 178510044、化合物収率 99.9%

試薬・触媒・溶媒 2

HCID 6101p-Toluenesulfonic acid触媒HCID 1140Toluene溶媒

実験手順

The mixture solution of 5-amino-pyridine-2-carbonitrile (9.3 g, 78.4 mmol), 3-morpholin-4-yl-benzaldehyde (15.0 g, 78.4 mmol) and p-toluenesulfonic acid (271.8 mg, 1.4 mmol) in toluene (150 mL) was heated to reflux for 12 h. Then the reaction mixture was cooled to room temperature. The solvent was removed in vacuo and the residue was washed with ether to afford 5-{[1-(3-morpholin-4-yl-phenyl)-meth-(E)-ylidene]-amino}-pyridine-2-carbonitrile (22.9 g, quant.) as a light yellow solid: MS (ESI) M+1=293.0.

後処理

  1. temperatureto reflux for 12 h
  2. customThe solvent was removed in vacuo
  3. washthe residue was washed with ether

出典と根拠

ORDレコード
ord-c9d7d888639e442fab511ab3e82ecc93
出典データセット
uspto-grants-2014_08
特許番号
US08809369B2

関連ノート

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