N-Iodosuccinimide → 6-(2-fluorophenyl)-7-iodo-5H-pyrrolo[3,2-d]pyrimidine

HRID 2408475ノート

反応式

HRID 2408475 の反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[NH:16][C:15]2[CH:14]=[N:13][CH:12]=[N:11][C:10]=2[CH:9]=1.[I:17]N1C(=O)CCC1=O>CC(C)=O.CCOC(C)=O>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[NH:16][C:15]2[CH:14]=[N:13][CH:12]=[N:11][C:10]=2[C:9]=1[I:17]

参加物

5

反応物 2

HCID 120273N-IodosuccinimideHCID 674703356-(2-fluorophenyl)-5H-pyrrolo[3,2-d]pyrimidine

生成物 1

HCID 674703526-(2-fluorophenyl)-7-iodo-5H-pyrrolo[3,2-d]pyrimidine収率 77%

試薬・触媒・溶媒 2

HCID 180Acetone溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a slurry of 6-(2-fluorophenyl)-5H-pyrrolo[3,2-d]pyrimidine (1.0 g) in acetone (25 mL) was added N-iodosuccinimide (1.4 g). The reaction was stirred at rt for 3 h, until complete conversion was observed by LC-MS. The reaction mixture was diluted with EtOAc (150 mL) and the solid was collected via filtration and washed with EtOAc yielding 1.23 g of desired (77% yield). LC-MS calculated for C12H7FIN3: 339.1, found 339.96 [M+].

後処理

  1. filtrationthe solid was collected via filtration
  2. washwashed with EtOAc yielding 1.23 g

出典と根拠

ORDレコード
ord-78ca2239abcf45bfa31e5107466f4df5
出典データセット
uspto-grants-2014_08
特許番号
US08815858B2

反応ノート

読み込み中…