Sodium Hydroxide → HCID 86698276、化合物
反応式
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[C:16]([C:20]1[Se:24][C:23]([C:25]([NH2:27])=[O:26])=[C:22]([OH:28])[CH:21]=1)([CH3:19])([CH3:18])[CH3:17].[OH-].[Na+]>CN(C=O)C>[CH3:13][O:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][C:8]=1[O:14][CH3:15])[N:5]=[CH:4][N:3]=[C:2]2[O:28][C:22]1[CH:21]=[C:20]([C:16]([CH3:19])([CH3:17])[CH3:18])[Se:24][C:23]=1[C:25]([NH2:27])=[O:26]参加物
5
実験手順
As shown in scheme R, 4-chloro-6,7-dimethoxyquinazoline is reacted with 5-tert-butyl-3-hydroxyselenophene-2-carboxamide in presence of NaOH and DMF to give 3-(6,7-dimethoxyquinazolin-4-yloxy)-5-tert-butylselenophene-2-carboxamide. The 5-tert-butyl-3-hydroxyselenophene-2-carboxamide is prepared in five steps from pinacolone and is described in examples.