2-chloro-5-nitropyridin-4-amine → 6-Chloropyridine-3,4-diamine

HRID 2409047

反応式

HRID 2409047 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([NH2:8])[C:5]([N+:9]([O-])=O)=[CH:4][N:3]=1>CCOC(C)=O.[Ni]>[Cl:1][C:2]1[N:3]=[CH:4][C:5]([NH2:9])=[C:6]([NH2:8])[CH:7]=1

参加物

4

反応物 1

HCID 109100582-chloro-5-nitropyridin-4-amine

生成物 1

HCID 8171336-Chloropyridine-3,4-diamine収率 107.4%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 2-chloro-5-nitropyridin-4-amine (4.50 g, 25.93 mmol) in EtOAc (100 mL) was added Raney nickel (0.45 g) followed by stirring under hydrogen at RT for 2 h. The reaction mixture was filtered and the filtrate concentrated under reduced pressure to afford 4.00 g (ca. 100%) of crude 6-chloropyridine-3,4-diamine as yellow oil. MS (ESI): m/z=144.3 [M+1]+.

後処理

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate concentrated under reduced pressure

出典と根拠

ORDレコード
ord-6be8b6661d27469f9649a4b31d83a784
出典データセット
uspto-grants-2014_08
特許番号
US08815877B2

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