化工社化工社 化学情報印刷レポート · 研究参考用
Benzenesulfonyl chloride → 1-Benzenesulfonyl-7-methoxy-1H-indole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzenesulfonyl chloride | HCID 7369 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 7-Methoxy-1H-indole | HCID 76660 | — |
| 反応物 | Water ethylacetate | HCID 22728543 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-Benzenesulfonyl-7-methoxy-1H-indole | HCID 11778801 | — |
反応手順
To a solution of 7-methoxyindole (1 eq) in DMF cooled in an ice bath was added NaH (60% dispersion in oil, 1.2 eq). The reaction was stirred for 1 hr at room temperature then recooled in an ice bath. Benzenesulfonyl chloride (1.1 eq) was added then the reaction was stirred for 2 hrs at room temperature. Water/ethyl acetate were added and the ethyl acetate layer was washed repeatedly (3×) with water. The ethyl acetate layer was concentrated and evaporated to dryness.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08648104B2 |
| 出典データセット | uspto-grants-2014_02 |
| ORD ID | ord-927b9b30e72649e2b62c4b069c86d747 |
| 出典メモ | uspto-grants-2014_02 |