Ammonium Chloride → HCID 69281520、化合物
反応式
[Cl:1][C:2]1[N:6]([CH:7]2[CH2:12][CH2:11][O:10][CH2:9][CH2:8]2)[N:5]=[CH:4][C:3]=1[N+:13]([O-])=O.[Cl-].[NH4+]>C(O)C.[Fe]>[Cl:1][C:2]1[N:6]([CH:7]2[CH2:8][CH2:9][O:10][CH2:11][CH2:12]2)[N:5]=[CH:4][C:3]=1[NH2:13]参加物
5
反応条件
- 温度
- 90 °C
実験手順
To a solution of 5-chloro-4-nitro-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole (0.4 g, 2 mmol) in ethanol (10 mL) was added ammonium chloride (0.3 g, 5 mmol) and iron (0.3 g). The reaction was stirred at 90° C. for 30 minutes before filtered through celite and concentrated. The residue was triturated in EtOAc and filtered. The filtrated was concentrated to give the title compound (0.34 g, quant.)
後処理
- filtrationbefore filtered through celite
- concentrationconcentrated
- customThe residue was triturated in EtOAc
- filtrationfiltered
- concentrationThe filtrated was concentrated
出典と根拠
- ORDレコード
- ord-7310cc93bfe14a4fa0b99947b5a47518
- 出典データセット
- uspto-grants-2014_08
- 特許番号
- US08815882B2
反応ノート
読み込み中…