2-Methyl-1H-imidazole-4-carboxaldehyde → (S)-2-Amino-6-{2-fluoro-5-[(2-methyl-3H-imidazol-4-ylmethyl)-amino]-phenyl}-3,5,5,6-tetramethyl-5,6-dihydro-3H-pyrimidin-4-one

HRID 2409164

反応式

HRID 2409164 の反応式
[NH2:1][C:2]1[N:7]([CH3:8])[C:6](=[O:9])[C:5]([CH3:11])([CH3:10])[C@:4]([C:13]2[CH:18]=[C:17]([NH2:19])[CH:16]=[CH:15][C:14]=2[F:20])([CH3:12])[N:3]=1.[CH3:21][C:22]1[NH:26][C:25]([CH:27]=O)=[CH:24][N:23]=1.[B][B][B][B][B][B][B][B][B][B]>>[NH2:1][C:2]1[N:7]([CH3:8])[C:6](=[O:9])[C:5]([CH3:10])([CH3:11])[C@:4]([C:13]2[CH:18]=[C:17]([NH:19][CH2:27][C:25]3[NH:26][C:22]([CH3:21])=[N:23][CH:24]=3)[CH:16]=[CH:15][C:14]=2[F:20])([CH3:12])[N:3]=1

参加物

4

反応物 3

HCID 27958782-Methyl-1H-imidazole-4-carboxaldehydeHCID 57497157HCID 57497157、化合物2 回HCID 178419135HCID 178419135、化合物

生成物 1

HCID 57497081(S)-2-Amino-6-{2-fluoro-5-[(2-methyl-3H-imidazol-4-ylmethyl)-amino]-phenyl}-3,5,5,6-tetramethyl-5,6-dihydro-3H-pyrimidin-4-one

実験手順

The reductive amination of (S)-2-amino-6-(5-amino-2-fluoro-phenyl)-3,5,5,6-tetramethyl-5,6-dihydro-3H-pyrimidin-4-one (intermediate J) and 2-methyl-3H-imidazole-4-carbaldehyde using decaborane yielded the title compound as a white solid. MS (ESI): m/z=373.2 [M+H]+.

出典と根拠

ORDレコード
ord-af97d473a6384e9fa054a926d8aa7400
出典データセット
uspto-grants-2014_08
特許番号
US08815881B2

関連ノート

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