Anisole → HCID 71178940、化合物

HRID 2409268ノート

反応式

HRID 2409268 の反応式
C([NH:5][S:6]([C:9]1[CH:10]=[N:11][N:12]2[C:17]([NH:18][C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:20]=3[CH3:26])=[C:16]([C:27]([N:29]3[CH2:34][CH2:33][CH:32]([C:35]4[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=4)[CH2:31][CH2:30]3)=[O:28])[CH:15]=[N:14][C:13]=12)(=[O:8])=[O:7])(C)(C)C.C1(OC)C=CC=CC=1>FC(F)(F)C(O)=O>[F:25][C:22]1[CH:23]=[CH:24][C:19]([NH:18][C:17]2[N:12]3[N:11]=[CH:10][C:9]([S:6]([NH2:5])(=[O:8])=[O:7])=[C:13]3[N:14]=[CH:15][C:16]=2[C:27]([N:29]2[CH2:34][CH2:33][CH:32]([C:35]3[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=3)[CH2:31][CH2:30]2)=[O:28])=[C:20]([CH3:26])[CH:21]=1

参加物

4

反応物 2

HCID 7519AnisoleHCID 71178956HCID 71178956、化合物

生成物 1

HCID 71178940HCID 71178940、化合物収率 56.1%

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

N-tert-Butyl-7-(4-fluoro-2-methylphenylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine-3-sulfonamide (0.874 g, 1.548 mmol) obtained in step 4 was dissolved in trifluoroacetic acid (13 mL), anisole (0.4 mL) was added, and the mixture was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure, the obtained residue was purified by silica gel column chromatography (chloroform/methanol=10/1) to give the title compound (0.442 g, 56%).

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe obtained residue was purified by silica gel column chromatography (chloroform/methanol=10/1)

出典と根拠

ORDレコード
ord-faf5461726e74e87b749c5b3c604b24b
出典データセット
uspto-grants-2014_08
特許番号
US08815874B2

反応ノート

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