HCID 58424985、化合物 → Ethyl 3-amino-5-methoxybenzoate
反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]=[C:12]([N+:14]([O-])=O)[CH:13]=1)[C:6]([O:8][CH2:9][CH3:10])=[O:7].[H][H]>C(OCC)(=O)C.[Pd]>[NH2:14][C:12]1[CH:11]=[C:5]([CH:4]=[C:3]([O:2][CH3:1])[CH:13]=1)[C:6]([O:8][CH2:9][CH3:10])=[O:7]参加物
5
実験手順
The compound (5.1 g, 23.1 mmol) prepared in step 2 was dissolved in ethyl acetate (50.0 ml), added with 10%-palladium (Pd) (100 mg). The resulting mixture was then stirred at room temperature for 24 hours in presence of hydrogen gas. After completion, 10%-palladium (Pd) was removed by celite-filter and the filtrate concentrated to dryness. The residue was purified by flash column chromatography (hexane:ethyl acetate=2:1) to obtain the title compound (4.36 g, yield: 96.8%, white solid).
後処理
- customAfter completion, 10%-palladium (Pd) was removed
- filtrationby celite-filter
- concentrationthe filtrate concentrated to dryness
- customThe residue was purified by flash column chromatography (hexane:ethyl acetate=2:1)
出典と根拠
- ORDレコード
- ord-0b8b5abadc8b4decabf1467fd024c965
- 出典データセット
- uspto-grants-2014_08
- 特許番号
- US08815891B2
反応ノート
読み込み中…