5-(3-Nitrophenyl)oxazole → 3-(1,3-Oxazol-5-yl)aniline
反応式
[N+:1]([C:4]1[CH:5]=[C:6]([C:10]2[O:14][CH:13]=[N:12][CH:11]=2)[CH:7]=[CH:8][CH:9]=1)([O-])=O>CO.[Pd]>[O:14]1[C:10]([C:6]2[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=2)[NH2:1])=[CH:11][N:12]=[CH:13]1参加物
4
実験手順
10% Pd/C (0.60 gm, 0.56 mmol) was added to a solution of 5-(3-Nitrophenyl)oxazole (5.80 gm, 30.50 mmol) in MeOH (122 mL). A H2 atmosphere was then introduced via balloon. After 24 h the reaction mixture was filtered through Celite. The catalyst was rinsed with MeOH and the filtrate was concentrated to give the product 3-(oxazol-5-yl)aniline (4.82 gm, 30.10 mmol, 99% yield) as a white solid. Anal. Calcd. for C9H6N2O3 m/z 160.1, found: 161.1 (M+H)+. Crude product was used without purification.
後処理
- additionA H2 atmosphere was then introduced via balloon
- filtrationAfter 24 h the reaction mixture was filtered through Celite
- washThe catalyst was rinsed with MeOH
- concentrationthe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-d3a6bb00c2f54760b16b57aea0aaf322
- 出典データセット
- uspto-grants-2014_08
- 特許番号
- US08815909B2
反応ノート
読み込み中…