1-(4-Methyl-3-nitrophenyl)ethan-1-ol → 1-(3-Amino-4-methylphenyl)ethan-1-ol
反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:10])[CH3:9])=[CH:4][C:3]=1[N+:11]([O-])=O>C(OCC)(=O)C.[Pd]>[NH2:11][C:3]1[CH:4]=[C:5]([CH:8]([OH:10])[CH3:9])[CH:6]=[CH:7][C:2]=1[CH3:1]参加物
4
実験手順
To a solution of 1-(4-methyl-3-nitrophenyl)ethan-1-ol (1.96 g) in ethyl acetate (55 mL) was added 10% palladium on carbon (56.5% water included, 901 mg), and the mixture was stirred at room temperature for 7 hours under a hydrogen atmosphere. The reaction mixture was filtered through celite (registered trademark) pad. The filtrate was concentrated under reduced pressure to obtain the title compound (1.60 g). 1H-NMR (CDCl3) δ ppm: 1.47 (3H, d, J=6.4 Hz), 1.73 (1H, br s), 2.16 (3H, s), 3.63 (2H, br s), 4.80 (1H, q, J=6.4 Hz), 6.66-6.75 (2H, m), 7.02 (1H, d, J=7.3 Hz).
後処理
- filtrationThe reaction mixture was filtered through celite (registered trademark) pad
- concentrationThe filtrate was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-6d67097930aa4b68bcec4c3dbc387f9d
- 出典データセット
- uspto-grants-2014_08
- 特許番号
- US08815903B2
反応ノート
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