3-Chloroaniline → HCID 86707780、化合物

HRID 2410136ノート

反応式

HRID 2410136 の反応式
[CH2:1]([O:3][C:4]([C:6]1[N:7]=[C:8]([Br:24])[N:9]([CH:21]([CH3:23])[CH3:22])[C:10]=1[CH:11]([C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=1[CH3:20])O)=[O:5])[CH3:2].[Cl:25][C:26]1[CH:27]=[C:28]([CH:30]=[CH:31][CH:32]=1)[NH2:29]>C(Cl)Cl.O>[CH2:1]([O:3][C:4]([C:6]1[N:7]=[C:8]([Br:24])[N:9]([CH:21]([CH3:23])[CH3:22])[C:10]=1[CH:11]([C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=1[CH3:20])[NH:29][C:28]1[CH:30]=[CH:31][CH:32]=[C:26]([Cl:25])[CH:27]=1)=[O:5])[CH3:2]

参加物

4

反応物 2

HCID 79323-ChloroanilineHCID 86707752HCID 86707752、化合物

生成物 1

HCID 86707780HCID 86707780、化合物

試薬・触媒・溶媒 1

HCID 21908982Water methylene chloride溶媒

実験手順

The title compound was prepared in analogy to the procedure described for step E2 with the intermediate C and the 3-chloroaniline. The reaction mixture was diluted in DCM/water and the phases were separated. The organic phase was dried (Na2SO4) and concentrated. The product was purified by flash chromatography (heptane/EtOAc, 9:1) to give the title compound. tR: 1.47 min (LC-MS 2); ESI-MS: 524.0/526.0/528.2 [M+H]+ (LC-MS 2).

後処理

  1. customThe title compound was prepared in analogy to the procedure
  2. customthe phases were separated
  3. dry with materialThe organic phase was dried (Na2SO4)
  4. concentrationconcentrated
  5. customThe product was purified by flash chromatography (heptane/EtOAc, 9:1)

出典と根拠

ORDレコード
ord-f35b6beeccf741868f98740febbe1eaf
出典データセット
uspto-grants-2014_08
特許番号
US08815926B2

反応ノート

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